All eastbound lanes of I-40 are closed near Exit 355 (NC 403) close to Newton Grove following a crash involving a tractor-trailer.
The road is expected to reopen by 10 a.m.
Five vehicles were involved in the collision: a UPS tractor-trailer, two tanker trucks, a bread truck, and a pickup truck.
Authorities have not yet released information on the conditions of the drivers.
Chopper 11 captured Faison Fire & Rescue crews spraying foam across the highway, suggesting a lengthy cleanup ahead.
Traffic was completely stopped as emergency teams worked to clear the scene.
